Part 1: The Profession of Medicine
Updated! Chapter 1: The Practice of Medicine
Updated! Chapter 2: Promoting Good Health
Updated! Chapter 3: Vaccine Opposition and Hesitancy
Updated! Chapter 4: Decision-Making in Clinical Medicine
Updated! Chapter 5: Precision Medicine and Clinical Care
New! Chapter 6: Screening and Prevention of Disease
Updated! Chapter 7: Global Diversity of Health System Financing and Delivery
Updated! Chapter 8: The Safety and Quality of Health Care
Updated! Chapter 9: Diagnosis: Reducing Errors and Improving Quality
New! Chapter 10: Racial and Ethnic Disparities in Health Care
Updated! Chapter 11: Ethical Issues in Clinical Medicine
New! Chapter 12: Palliative and End-of-Life Care
Part 2: Cardinal Manifestations and Presentation of Diseases
Section 1: Pain
New! Chapter 13: Pain: Pathophysiology and Management
New! Chapter 14: Chest Discomfort
New! Chapter 15: Abdominal Pain
New! Chapter 16: Headache
New! Chapter 17: Back and Neck Pain
Section 2: Fever
New! Chapter 18: Fever
New! Chapter 19: Fever and Rash
New! Chapter 20: Fever of Unknown Origin
Section 3: Nervous System Dysfunction
New! Chapter 21: Syncope
Updated! Chapter 22: Dizziness and Vertigo
New! Chapter 23: Fatigue
New! Chapter 24: Neurologic Causes of Weakness and Paralysis
New! Chapter 25: Numbness, Tingling, and Sensory Loss
New! Chapter 26: Gait Disorders, Imbalance, and Falls
Updated! Chapter 27: Confusion and Delirium
New! Chapter 28: Coma
New! Chapter 29: Dementia
New! Chapter 30: Aphasia, Memory Loss, and Other Cognitive Disorders
New! Chapter 31: Sleep Disorders
Section 4: Disorders of Eyes, Ears, Nose, and Throat
New! Chapter 32: Disorders of the Eye
New! Chapter 33: Disorders of Smell and Taste
New! Chapter 34: Disorders of Hearing
New! Chapter 35: Upper Respiratory Symptoms, Including Earache, Sinus Symptoms, and Sore Throat
New! Chapter 36: Oral Manifestations of Disease
Section 5: Alterations in Circulatory and Respiratory Functions
New! Chapter 37: Dyspnea
New! Chapter 39: Hemoptysis
New! Chapter 38: Cough
New! Chapter 40: Hypoxia and Cyanosis
New! Chapter 41: Edema
New! Chapter 43: Palpitations
Section 6: Alterations in Gastrointestinal Function
New! Chapter 44: Dysphagia
New! Chapter 45: Nausea, Vomiting, and Indigestion
New! Chapter 46: Diarrhea and Constipation
New! Chapter 47: Unintentional Weight Loss
Updated! Chapter 48: Gastrointestinal Bleeding
New! Chapter 49: Jaundice
Updated! Chapter 50: Abdominal Swelling and Ascites
Section 7: Alterations in Renal and Urinary Tract Function
New! Chapter 51: Interstitial Cystitis/Bladder Pain Syndrome
New! Chapter 52: Azotemia and Urinary Abnormalities
New! Chapter 54: Hypercalcemia and Hypocalcemia
New! Chapter 55: Acidosis and Alkalosis
Section 8: Alterations in the Skin
New! Chapter 56: Approach to the Patient with a Skin Disorder
New! Chapter 57: Eczema, Psoriasis, Cutaneous Infections, Acne, and Other Common Skin Disorders
New! Chapter 58: Skin Manifestations of Internal Disease
New! Chapter 59: Immunologically Mediated Skin Diseases
New! Chapter 60: Cutaneous Drug Reactions
New! Chapter 61: Photosensitivity and Other Reactions to Sunlight
Section 9: Hematologic Alterations
New! Chapter 62: Interpreting Peripheral Blood Smears
New! Chapter 63: Anemia and Polycythemia
New! Chapter 64: Disorders of Granulocytes and Monocytes
New! Chapter 65: Bleeding and Thrombosis
New! Chapter 66: Enlargement of Lymph Nodes and Spleen
Part 3: Pharmacology
New! Chapter 67: Principles of Clinical Pharmacology
Updated! Chapter 68: Pharmacogenomics
Part 4: Oncology and Hematology
Section 1: Neoplastic Disorders
New! Chapter 70: Prevention and Early Detection of Cancer
New! Chapter 71: Cancer Genetics
New! Chapter 72: Cancer Cell Biology
New! Chapter 73: Principles of Cancer Treatment
New! Chapter 75: Oncologic Emergencies
New! Chapter 76: Cancer of the Skin
New! Chapter 77: Head and Neck Cancer
New! Chapter 80: Upper Gastrointestinal Tract Cancers
New! Chapter 81: Lower Gastrointestinal Cancers
New! Chapter 82: Tumors of the Liver and Biliary Tree
New! Chapter 85: Renal Cell Carcinoma
New! Chapter 86: Cancer of the Bladder and Urinary Tract
New! Chapter 87: Benign and Malignant Diseases of the Prostate
New! Chapter 88: Testicular Cancer
New! Chapter 89: Gynecologic Malignancies
New! Chapter 90: Primary and Metastatic Tumors of the Nervous System
New! Chapter 91: Soft Tissue and Bone Sarcomas and Bone Metastases
New! Chapter 93: Paraneoplastic Syndromes: Endocrinologic/Hematologic
New! Chapter 95: Cancer Survivorship and the Long-Term Impact of Cancer and Its Treatment
Section 2: Hematopoietic Disorders
New! Chapter 96: Hematopoietic Stem Cells
New! Chapter 97: Iron Deficiency and Other Hypoproliferative Anemias
New! Chapter 99: Megaloblastic Anemias
New! Chapter 101: Anemia Due to Acute Blood Loss
New! Chapter 102: Bone Marrow Failure Syndromes Including Aplastic Anemia and Myelodysplasia
New! Chapter 103: Polycythemia Vera and Other Myeloproliferative Neoplasms
New! Chapter 105: Chronic Myeloid Leukemia
New! Chapter 108: Non-Hodgkin’s Lymphoma
New! Chapter 109: Hodgkin’s Lymphoma
New! Chapter 112: Amyloidosis
New! Chapter 113: Transfusion Therapy and Biology
New! Chapter 114: Hematopoietic Cell Transplantation
Section 3: Disorders of Hemostasis
New! Chapter 115: Disorders of Platelets and Vessel Wall
New! Chapter 118: Antiplatelet, Anticoagulant, and Fibrinolytic Drugs
Part 5: Infectious Diseases
Section 2: Clinical Syndromes: Community-Acquired Infections
New! Chapter 126: Pneumonia
New! Chapter 138: Acute Meningitis
New! Chapter 139: Chronic and Recurrent Meningitis
New! Chapter 140: Brain Abscess and Empyema
New! Chapter 141: Infectious Complications of Bites
Section 3: Clinical Syndromes: Health Care-Associated Infections
New! Chapter 142: Infections Acquired in Health Care Facilities
New! Chapter 143: Infections in Transplant Recipients
Section 4: Therapy for Bacterial Diseases
New! Chapter 144: Treatment and Prophylaxis of Bacterial Infections
New! Chapter 145: Bacterial Resistance to Antimicrobial Agents
Section 5: Diseases Caused by Gram-Positive Bacteria
New! Chapter 146: Pneumococcal Infections
New! Chapter 147: Staphylococcal Infections
New! Chapter 148: Streptococcal Infections
New! Chapter 149: Enterococcal Infections
New! Chapter 150: Diphtheria and Other Corynebacterial Infections
New! Chapter 151: Listeria monocytogenes Infections
New! Chapter 152: Tetanus
New! Chapter 153: Botulism
New! Chapter 154: Gas Gangrene and Other Clostridial Infections
Section 6: Diseases Caused by Gram-Negative Bacteria
New! Chapter 155: Meningococcal Infections
New! Chapter 157: Haemophilus and Moraxella Infections
New! Chapter 158: Infections Due to the HACEK Group and Miscellaneous Gram-Negative Bacteria
New! Chapter 159: Legionella Infections
New! Chapter 160: Pertussis and Other Bordetella Infections
New! Chapter 161: Diseases Caused by Gram-Negative Enteric Bacilli
New! Chapter 162: Acinetobacter Infections
Part 7: Disorders of the Respiratory System
Section 1: Diagnosis of Respiratory Disorders
New! Chapter 284: Approach to the Patient with Disease of the Respiratory System
New! Chapter 285: Disturbances of Respiratory Function
Section 2: Diseases of the Respiratory System
New! Chapter 288: Hypersensitivity Pneumonitis and Pulmonary Infiltrates with Eosinophilia
Part 9: Disorders of the Kidney and Urinary Tract
New! Chapter 309: Cell Biology and Physiology of the Kidney
New! Chapter 312: Dialysis in the Treatment of Kidney Failure
New! Chapter 314: Glomerular Diseases
New! Chapter 315: Polycystic Kidney Disease and Other Inherited Disorders of Tubule Growth and Development
New! Chapter 317: Vascular Injury to the Kidney
New! Chapter 318: Nephrolithiasis
New! Chapter 319: Urinary Tract Obstruction
New! Chapter 320: Interventional Nephrology
Part 11: Immune-Mediated, Inflammatory, and Rheumatologic Disorders
Section 2: Disorders of Immune-Mediated Injury
New! Chapter 353: Anaphylaxis
New! Chapter 354: Mastocytosis
New! Chapter 357: Antiphospholipid Syndrome
New! Chapter 361: Sjögren’s Syndrome
New! Chapter 364: Behçet Syndrome
Part 12: Endocrinology and Metabolism
Section 1: Endocrinology
New! Chapter 383: Hypothyroidism
Part 13: Neurologic Disorders
Section 2: Diseases of the Central Nervous System
New! Chapter 431: Alzheimer’s Disease